Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.64 |
| ▸ | APAF1 | O14727 | 2/20 | 0.64 |
| ▸ | NSD2 | O96028 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | TDP2 | O95551 | 1/20 | 0.53 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991450 | 0.94 | CASP3 (0.65) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7991749 | 0.89 | CASP3 (0.61) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7995165 | 0.88 | CASP3 (0.60) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7991698 | 0.86 | CASP3 (0.57) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL23458036 | 0.86 | CASP3 (0.76) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7989463 | 0.80 | CASP3 (0.61) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL23458028 | 0.80 | CASP3 (0.78) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL21690569 | 0.79 | CASP3 (0.77) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7987788 | 0.79 | MAOB (0.50) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL679695 | 0.79 | CASP3 (1.00) | CASP3SENP6SENP8SENP7APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001055117-A1 | NOVEL ISOQUINOLINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2001-08-02 | — | — | WO | disclosed |