Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.59 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | GCGR | P47871 | 4/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988569 | 0.87 | ALOX5 (0.48) | ALOX5PKN1PKN2TARBP2KDM4E | |
| SCHEMBL7995163 | 0.86 | MMP13 (0.55) | ALOX5MMP2MMP13MMP14TARBP2 | |
| SCHEMBL7991975 | 0.84 | MAPK14 (0.49) | ALOX5PKN1PKN2GCGRMAPK14 | |
| SCHEMBL7988441 | 0.83 | AR (0.55) | MMP2MMP13TARBP2MAPK14SMN1; SMN2 | |
| SCHEMBL7977738 | 0.83 | MAPK14 (0.56) | ALOX5GCGRMAPK14MAPK13MAPK12 | |
| SCHEMBL7992039 | 0.83 | MAPK14 (0.56) | ALOX5GCGRMAPK14MAPK13MAPK12 | |
| SCHEMBL28582964 | 0.83 | TARBP2 (0.54) | ALOX5TARBP2KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL7995926 | 0.82 | KDM4E (0.49) | TARBP2MAPK14KDM4ETP53SMN1; SMN2 | |
| SCHEMBL7988152 | 0.82 | SIRT2 (0.61) | ALOX5TARBP2KDM4ETP53SMN1; SMN2 | |
| SCHEMBL7988588 | 0.80 | PRMT5 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, VPS4B, PIK3C2A | ALOX5 3170/4885PKN1 2959/4885PKN2 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.