SCHEMBL7991923

SCHEMBL7991923

CC(=O)c1ccccc1CCC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.44
LMNA P02545 4/20 0.44
FOLH1 Q04609 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 2/20 0.41
ADRB2 P07550 1/20 0.39
CYP3A4 P08684 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP2D6 P10635 1/20 0.38
PDK1 Q15118 1/20 0.37
PDK2 Q15119 1/20 0.37
PDK3 Q15120 1/20 0.37
PDK4 Q16654 1/20 0.37
HTT P42858 1/20 0.36
CYP1A2 P05177 1/20 0.36
BRS3 P32247 1/20 0.35
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
RIPK1 Q13546 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6445972 0.85 FOLH1 (0.59) ALDH1A1FOLH1SMN1; SMN2KDM4EHTT
SCHEMBL1995924 0.84 ALDH1A1 (0.42) ALDH1A1LMNAFOLH1KDM4ECYP3A4
SCHEMBL28890207 0.81 AKR1C3 (0.47) ALDH1A1FOLH1KDM4ETSHR
SCHEMBL2125820 0.79 ALDH1A1 (0.47) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E
SCHEMBL19291183 0.79 PTPN1 (0.50) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E
SCHEMBL30628269 0.79 ALDH1A1 (0.47) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E
SCHEMBL5609826 0.79 ALDH1A1 (0.47) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E
SCHEMBL6480908 0.77 LMNA (0.41) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E
SCHEMBL5609024 0.77 ALDH1A1 (0.46) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E
SCHEMBL5696477 0.77 ALDH1A1 (0.46) ALDH1A1LMNAFOLH1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291716-B1 INTRODUCING ALKYL MOIETY TO AN ORTHO-POSITION OF THE AROMATIC KETONE IN PRESENCE OF A PRIMARY AMINE AND TRANSITION METAL CATALYST, ALKYL MOIETY COMPOUND BEING SOURCED FROM ALIPHATIC OR AROMATIC OLEFINS, INTERNAL OLEFINS OR DIENES Jun, Chul Ho (KR) 2001-09-18 US disclosed