Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991049 | 0.88 | PDE4A (0.41) | PDE4AKCNH2GPR119 | |
| SCHEMBL7990922 | 0.83 | PDE4A (0.53) | PDE4AKCNH2 | |
| SCHEMBL7462478 | 0.82 | PDE4A (0.64) | PDE4AKCNH2 | |
| SCHEMBL7992704 | 0.78 | F7 (0.36) | PDE4AKCNH2GPR119 | |
| SCHEMBL7991120 | 0.71 | ALOX5 (0.39) | PDE4AKCNH2 | |
| SCHEMBL7991436 | 0.71 | PDE4A (0.38) | PDE4AKCNH2 | |
| SCHEMBL7977060 | 0.69 | HSPB1 (0.48) | — | |
| SCHEMBL5942690 | 0.69 | PDE4A (0.40) | PDE4AKCNH2 | |
| SCHEMBL7990939 | 0.69 | PDE4A (0.67) | PDE4AKCNH2 | |
| SCHEMBL7991272 | 0.68 | LMNA (0.50) | PDE4ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |