SCHEMBL7994863

SCHEMBL7994863

C=C[SiH](O)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.38
ALDH1A1 P00352 1/20 0.38
AKT1 P31749 1/20 0.36
ALOX15 P16050 1/20 0.33
TGM2 P21980 1/20 0.32
DAO P14920 1/20 0.32
NAPRT Q6XQN6 1/20 0.32
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
GLA P06280 1/20 0.30
CA3 P07451 1/20 0.30
CA4 P22748 1/20 0.30
CA9 Q16790 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
CA14 Q9ULX7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1712669 0.72 TSHR (0.41) TSHRALDH1A1AKT1ALOX15TGM2
SCHEMBL217350 0.72 TSHR (0.41) TSHRALDH1A1AKT1ALOX15TGM2
Fluoride SCHEMBL27718731 0.70 TSHR (0.39) TSHRALDH1A1AKT1ALOX15
SCHEMBL19891671 0.70 AKT1 (0.38) TSHRALDH1A1AKT1ALOX15TGM2
SCHEMBL9267683 0.69 CYP1A2 (0.35) TSHRALDH1A1AKT1
SCHEMBL28561480 0.69 TSHR (0.33) TSHRALDH1A1AKT1ALOX15
SCHEMBL2270554 0.68 ALDH1A1 (0.38) TSHRALDH1A1AKT1
SCHEMBL16508016 0.68 TSHR (0.38) TSHRALDH1A1AKT1
SCHEMBL1066599 0.68 TSHR (0.38) TSHRALDH1A1AKT1ALOX15TGM2
SCHEMBL10867723 0.68 ALDH1A1 (0.38) TSHRALDH1A1AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111278926-B Curable silicone composition, resin sheet for optical member containing same, and light-emitting device 陶氏东丽株式会社 2022-06-07 CN disclosed
US-20200216671-A1 CURABLE SILICONE COMPOSITION, OPTICAL MEMBER RESIN SHEET COMPRISING SAME, AND LIGHT-EMITTING DEVICE DOW TORAY CO., LTD. (JP) 2020-07-09 US disclosed
CN-111278926-A Curable silicone composition, resin sheet for optical member containing same, and light-emitting device 陶氏东丽株式会社 2020-06-12 CN disclosed
CN-103249762-A Addition-curable metallosiloxane compound DAICEL CORP 2013-08-14 CN disclosed
US-6284829-B1 FILLER COMPRISING AT LEAST TWO GROUPS OF PARTICLES OF VERY DIFFERENT MEAN DIAMETERS RHODIA CHIMIE (FR) 2001-09-04 US disclosed
US-5916940-A 100 PARTS BY WEIGHT OF A POLYDIORGANOSILOXANE GUM, 10 TO 150 PARTS BY WEIGHT OF FINELY POWDERED SILICA, 0.01 TO 20 PARTS BY WEIGHT OF A ZINC COMPOUND, AND 0.1 TO 10 PARTS BY WEIGHT OF A METHYL-GROUP-SUBSTITUTED BENZOYL PEROXIDE. DOW CORNING TORAY SILICONE CO., LTD. (JP) 1999-06-29 US disclosed