Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.54 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.54 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.45 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995248 | 0.92 | ITGAV (0.68) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7380582 | 0.86 | ITGAV (0.47) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7374387 | 0.78 | ITGAV (0.54) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6423205 | 0.77 | ITGB3 (0.81) | ITGAVITGB3ITGB5ITGB6ITGB8 | |
| SCHEMBL6421882 | 0.77 | ITGAV (0.73) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7995002 | 0.76 | ITGB3 (0.82) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7953104 | 0.76 | ITGAV (0.79) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6424883 | 0.74 | ITGAV (0.60) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6424882 | 0.74 | ITGAV (0.60) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL29482189 | 0.74 | ITGAV (0.71) | ITGAVITGB3ITGA2BITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294549-B1 | COMPOUNDS USEFUL FOR INHIBITING RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, INFLAMMATION OR TUMOR GROWTH. | MERCK & CO., INC. | 2001-09-25 | — | — | US | disclosed |