Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.38 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883238 | 0.83 | PDE5A (0.43) | ABCB11MEN1KMT2AGAKRIPK2 | |
| SCHEMBL8184699 | 0.81 | KMT2A (0.42) | ABCB11MEN1KMT2AGAKRIPK2 | |
| SCHEMBL17188735 | 0.81 | ACHE (0.42) | CSNK2A2CSNK2BCSNK2A1MEN1KMT2A | |
| SCHEMBL13830533 | 0.80 | TDO2 (0.43) | GAKCYP1A2AMY1A | |
| SCHEMBL29122012 | 0.80 | PDE5A (0.41) | MEN1KMT2AGAKRIPK2COQ8A | |
| SCHEMBL27919960 | 0.80 | TRPV4 (0.40) | ABCB11MEN1KMT2AGAKRIPK2 | |
| SCHEMBL8273112 | 0.78 | ROCK2 (0.39) | ABCB11MEN1KMT2AGAKRIPK2 | |
| SCHEMBL3430430 | 0.78 | L3MBTL1 (0.39) | ABCB11GAKRIPK2COQ8ANLK | |
| SCHEMBL3478846 | 0.78 | PDE10A (0.47) | ALDH1A1MAPTHPGDHTTTDP1 | |
| SCHEMBL12054562 | 0.77 | CA1 (0.43) | MEN1KMT2AALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2813500-B1 | Intermediates for the preparation of hepatitis C virus inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2016-08-17 | — | — | EP | disclosed |
| EP-2283018-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-04-13 | — | — | EP | disclosed |
| EP-2265606-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-10-21 | — | — | EP | disclosed |
| EP-2813500-A1 | Intermediates for the preparation of hepatitis C virus inhibitors | Bristol-Myers Squibb Company (US) | 2014-12-17 | — | — | EP | disclosed |
| WO-2011150190-A2 | HCV INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ANACOR PHARMACEUTICALS, INC. (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2009129109-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009085659-A1 | CRYSTALLINE FORMS OF N-(TERT-BUTOXYCARBONYL)-3-METHYL-L-VALYL-(4R)-4-((7-CHLORO-4-METHOXY-1-ISOQUINOLINYL)OXY)-N-((1R,2S)-1-((CYCLOPROPYLSULFONYL)CARBAMOYL)-2-VINYLCYCLOPROPYL)-L-PROLINAMIDE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2008060927-A2 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-22 | — | — | WO | disclosed |