Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.63 |
| ▸ | HTR3A | P46098 | 10/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996707 | 0.81 | HTR1A (0.63) | HTR1AHTR3AHRH3DRD2DRD3 | |
| SCHEMBL7993109 | 0.81 | HTR1A (0.61) | HTR1AHTR3AHRH3HTR3EKDM4E | |
| SCHEMBL7991688 | 0.80 | RAB9A (0.54) | HTR1AHTR3ACYP1A2 | |
| SCHEMBL7993335 | 0.75 | HTR1A (0.62) | HTR1AHTR3AHRH3DRD2DRD3 | |
| SCHEMBL9602546 | 0.75 | HTR1A (0.67) | HTR1AHTR3AHRH3HTR3EKDM4E | |
| SCHEMBL7990516 | 0.74 | HTR1A (0.60) | HTR1AKDM4EALDH1A1CYP1A2DRD2 | |
| SCHEMBL7686047 | 0.74 | HTR1A (0.57) | HTR1AHTR3AHRH3HTR3EKDM4E | |
| SCHEMBL7996576 | 0.73 | HTR1A (0.59) | HTR1ADRD2HTR7 | |
| SCHEMBL3679755 | 0.73 | HTR1A (0.65) | HTR1AHTR3AHRH3HTR3EKDM4E | |
| SCHEMBL647772 | 0.73 | HTR1A (0.65) | HTR1AHTR3AHRH3HTR3EKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| US-5371087-A | Antipsychotic, analgesics, anticonvulsant and anxiolytic agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5229388-A | 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |