Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000551 | 0.80 | HPGD (0.64) | HPGDPPARG | |
| SCHEMBL8000557 | 0.80 | HPGD (0.64) | HPGDPPARG | |
| SCHEMBL7987983 | 0.77 | LMNA (0.55) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL2231854 | 0.76 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21399403 | 0.76 | SMN1; SMN2 (0.46) | LMNAALDH1A1MAPTSMN1; SMN2LTA4H | |
| SCHEMBL2232274 | 0.76 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL2232493 | 0.76 | ALDH1A1 (0.63) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7996783 | 0.76 | MAPT (0.57) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL2231178 | 0.76 | ALDH1A1 (0.66) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL2231514 | 0.76 | ALDH1A1 (0.63) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |
| EP-0991632-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057941-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |