Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006543 | 0.83 | PARP10 (0.58) | SMN1; SMN2POLBALDH1A1LMNAMAPT | |
| SCHEMBL6711589 | 0.80 | TAAR1 (0.44) | SMN1; SMN2TAAR1LTA4HPLA2G2ACYP19A1 | |
| SCHEMBL7615944 | 0.77 | CA1 (0.53) | SMN1; SMN2ALDH1A1MAPTESR2 | |
| SCHEMBL7996955 | 0.76 | LMNA (0.49) | SMN1; SMN2LTA4HALDH1A1LMNAMAPT | |
| SCHEMBL10754241 | 0.75 | ALDH1A1 (0.59) | SMN1; SMN2TAAR1ALDH1A1MAPTCYP19A1 | |
| Hydrochloric Acid SCHEMBL12503056 | 0.73 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1MAPTCYP19A1ESR1 | |
| SCHEMBL6122034 | 0.73 | PARP10 (0.70) | TAAR1ALDH1A1CYP19A1ESR1ESR2 | |
| SCHEMBL6714503 | 0.73 | TAAR1 (0.75) | SMN1; SMN2TAAR1LTA4HPLA2G2AALDH1A1 | |
| SCHEMBL27321565 | 0.73 | LOXL2 (0.44) | SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL926743 | 0.72 | ALOX5 (0.50) | SMN1; SMN2LTA4HKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182942-A1 | TYROSINE-SPECIFIC FUNCTIONALIZED INSULIN AND INSULIN ANALOGS | MERCK SHARP & DOHME CORP. (US) | 2019-09-26 | — | — | WO | disclosed |