Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223963 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TDP1CYP3A4TSHRMAPT | |
| SCHEMBL1503408 | 0.83 | MAPT (0.57) | ALDH1A1TDP1CASP1CYP3A4TSHR | |
| SCHEMBL11122473 | 0.83 | MAPT (0.57) | ALDH1A1TDP1CASP1CYP3A4TSHR | |
| SCHEMBL588896 | 0.81 | CA2 (0.61) | ALDH1A1TDP1CASP1CYP3A4TSHR | |
| SCHEMBL1368132 | 0.81 | G6PD (0.55) | ALDH1A1TDP1CASP1CYP3A4TSHR | |
| SCHEMBL10412670 | 0.80 | LMNA (0.61) | ALDH1A1TDP1TSHRMAPTLMNA | |
| SCHEMBL10391068 | 0.80 | ALDH1A1 (0.61) | ALDH1A1TDP1CYP3A4TSHRMAPT | |
| SCHEMBL6265475 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TDP1CASP1CYP3A4TSHR | |
| SCHEMBL155923 | 0.79 | ALDH1A1 (0.62) | ALDH1A1TDP1CASP1CYP3A4TSHR | |
| SCHEMBL9651561 | 0.79 | TDP1 (0.67) | ALDH1A1TDP1CASP1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921790-A4 | SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | UNIV TEXAS (US) | 2000-11-02 | — | — | EP | claimed |
| EP-0921790-A1 | SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | The Board of Regents, The University of Texas System (US) | 1999-06-16 | — | — | EP | claimed |
| US-5798392-A | IRREVERSIBLE ACETYLCHOLINESTERASE INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-08-25 | — | — | US | claimed |
| WO-1998008497-A1 | SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-03-05 | — | — | WO | claimed |
| EP-0921790-A4 | SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | UNIV TEXAS (US) | 2000-11-02 | — | — | EP | disclosed |
| EP-0921790-A1 | SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | The Board of Regents, The University of Texas System (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5798392-A | IRREVERSIBLE ACETYLCHOLINESTERASE INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-08-25 | — | — | US | disclosed |
| WO-1998008497-A1 | SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-03-05 | — | — | WO | disclosed |