Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 12/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | SPR | P35270 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993961 | 0.86 | HTR2A (0.53) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL7997830 | 0.86 | HTR2A (0.53) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL7997354 | 0.81 | GPR84 (0.48) | MPOSLC6A4NOTUMHTR2ATRPM8 | |
| SCHEMBL7983652 | 0.81 | SLC6A4 (0.41) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL25428141 | 0.80 | MPO (0.50) | MPOSLC6A4HTR1A | |
| SCHEMBL7984083 | 0.80 | HTR2B (0.52) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL7983657 | 0.80 | GPR84 (0.49) | MPOSLC6A4NOTUMHTR2ATRPM8 | |
| SCHEMBL8001578 | 0.77 | HTR2A (0.57) | MPONOTUMHTR2ATRPM8HTR1A | |
| SCHEMBL7997990 | 0.77 | HTR2A (0.57) | MPONOTUMHTR2ATRPM8HTR1A | |
| SCHEMBL7995675 | 0.77 | HTR2A (0.57) | MPONOTUMHTR2ATRPM8HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040183-A1 | 1-AMINOALKYL-1H-INDOLES FOR TREATING GLAUCOMA | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |