SCHEMBL7999224

SCHEMBL7999224

Cc1ccc(S(=O)(=O)Sc2cc(C)c(NS(=O)(=O)c3ccc(C#N)cc3)cc2C(C)(C)C)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
GAA P10253 3/20 0.44
GFER P55789 1/20 0.44
RXFP1 Q9HBX9 1/20 0.43
BCHE P06276 1/20 0.42
ACHE P22303 1/20 0.42
LMNA P02545 2/20 0.41
HTT P42858 1/20 0.41
BRD1 O95696 3/20 0.41
BRPF1 P55201 3/20 0.41
BRPF3 Q9ULD4 3/20 0.41
HSD11B1 P28845 3/20 0.40
KMT2A Q03164 1/20 0.40
BRD4 O60885 3/20 0.39
BRD9 Q9H8M2 2/20 0.39
BRD7 Q9NPI1 1/20 0.39
ACLY P53396 1/20 0.39
HSD17B2 P37059 2/20 0.38
IDO1 P14902 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5881054 0.87 ALDH1A1 (0.47) ALDH1A1GAAGFERLMNAHTT
SCHEMBL5880727 0.79 BCHE (0.42) ALDH1A1GAAGFERBCHEACHE
SCHEMBL5880931 0.76 LMNA (0.42) ALDH1A1LMNAKMT2AIDO1
SCHEMBL5880910 0.75 MEN1 (0.41) ALDH1A1GAAGFERBCHEACHE
SCHEMBL8702569 0.73 DNMT1 (0.46) ALDH1A1GAABCHEACHEKMT2A
SCHEMBL5880835 0.72 DNMT1 (0.45) ALDH1A1GAABCHEACHELMNA
SCHEMBL8008611 0.72 DNMT1 (0.45) ALDH1A1GAAGFERBCHEACHE
SCHEMBL6303180 0.72 HTR6 (0.40) BCHEACHEKMT2A
Hydrochloric Acid SCHEMBL5880769 0.71 DNMT1 (0.44) ALDH1A1GAABCHEACHELMNA
SCHEMBL7587888 0.70 KEAP1 (0.54) ALDH1A1GAAGFERLMNAHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US claimed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP claimed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO claimed
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed