Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.48 |
| ▸ | RXRB | P28702 | 6/20 | 0.48 |
| ▸ | RXRG | P48443 | 6/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27905706 | 0.86 | RXRA (0.51) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL30120834 | 0.82 | IDO1 (0.51) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL5574328 | 0.82 | CES2 (0.53) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL892902 | 0.82 | IDO1 (0.51) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL30201250 | 0.81 | ALDH1A1 (0.52) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL20575945 | 0.81 | RXRA (0.57) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL30120956 | 0.81 | RXRA (0.57) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL1775542 | 0.81 | ALDH1A1 (0.52) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL3827119 | 0.81 | RXRA (0.47) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL3135089 | 0.80 | RXRA (0.53) | RXRARXRBRXRGPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |