Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514134 | 0.80 | XPO1 (0.41) | GAAMAPTXPO1MEN1KMT2A | |
| SCHEMBL7965692 | 0.80 | ATR (0.42) | RAB9AGAAXPO1MEN1KMT2A | |
| SCHEMBL25310109 | 0.69 | GPR27 (0.40) | HTTGAAXPO1MEN1KMT2A | |
| SCHEMBL14684399 | 0.68 | NNMT (0.37) | SMN1; SMN2L3MBTL1RAB9AMEN1KMT2A | |
| SCHEMBL26803352 | 0.66 | SLC6A12 (0.39) | XPO1 | |
| SCHEMBL22693561 | 0.66 | S1PR2 (0.56) | ADORA2ASMN1; SMN2HTTL3MBTL1HPGD | |
| SCHEMBL16084274 | 0.66 | CSNK1D (0.39) | CSNK1DSMN1; SMN2HTTL3MBTL1HPGD | |
| SCHEMBL5374156 | 0.66 | L3MBTL1 (0.42) | SMN1; SMN2HTTL3MBTL1HPGDRAB9A | |
| SCHEMBL1119560 | 0.66 | TUBB4A (0.33) | HTTXPO1 | |
| SCHEMBL1169061 | 0.64 | MAPT (0.40) | SMN1; SMN2HTTL3MBTL1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138176-A1 | SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AS GSK3BETA-INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-11-19 | — | — | WO | disclosed |