Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.60 |
| ▸ | MMP14 | P50281 | 11/20 | 0.60 |
| ▸ | MMP1 | P03956 | 8/20 | 0.60 |
| ▸ | MMP13 | P45452 | 7/20 | 0.60 |
| ▸ | MMP2 | P08253 | 7/20 | 0.60 |
| ▸ | MMP8 | P22894 | 6/20 | 0.60 |
| ▸ | MMP3 | P08254 | 5/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.48 |
| ▸ | MMP7 | P09237 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001764 | 0.82 | MMP9 (0.46) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL8000234 | 0.79 | MMP9 (0.55) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL6687124 | 0.75 | MMP14 (1.00) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL8002839 | 0.73 | MMP9 (0.53) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL7990360 | 0.72 | MMP9 (0.60) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL8000272 | 0.71 | MMP2 (0.65) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL27509205 | 0.70 | MMP1 (0.66) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL8001945 | 0.70 | MMP14 (0.60) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL18711920 | 0.69 | MEN1 (0.55) | MMP9MMP14MMP1MMP13MMP2 | |
| SCHEMBL7307938 | 0.69 | MMP13 (0.70) | MMP9MMP14MMP1MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |