Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.75 |
| ▸ | MMP1 | P03956 | 14/20 | 0.75 |
| ▸ | MMP9 | P14780 | 13/20 | 0.75 |
| ▸ | MMP14 | P50281 | 12/20 | 0.75 |
| ▸ | MMP8 | P22894 | 12/20 | 0.75 |
| ▸ | MMP2 | P08253 | 11/20 | 0.75 |
| ▸ | MMP3 | P08254 | 10/20 | 0.75 |
| ▸ | MMP7 | P09237 | 2/20 | 0.75 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | MMP10 | P09238 | 1/20 | 0.75 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001945 | 0.90 | MMP14 (0.60) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL7990308 | 0.89 | MMP1 (0.59) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL7301710 | 0.88 | MMP1 (0.80) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL7308448 | 0.87 | MMP1 (0.81) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL7306093 | 0.87 | MMP1 (0.81) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL3984079 | 0.86 | MMP1 (0.80) | MMP13MMP1MMP9MMP14MMP8 | |
| Cts-1027 SCHEMBL2381112 | 0.86 | MMP1 (1.00) | MMP13MMP1MMP9MMP14MMP8 | |
| Hydrochloric Acid SCHEMBL7349688 | 0.84 | MMP13 (0.77) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL8000272 | 0.84 | MMP2 (0.65) | MMP13MMP1MMP9MMP14MMP8 | |
| SCHEMBL7990360 | 0.84 | MMP9 (0.60) | MMP13MMP1MMP9MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |