Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.31 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985289 | 0.83 | GLRA1 (0.37) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL19833104 | 0.80 | ODC1 (0.32) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL19925599 | 0.79 | LMNA (0.43) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL1162074 | 0.78 | CA12 (0.48) | HDAC3LMNATSHRHDAC4HDAC1 | |
| SCHEMBL4432164 | 0.77 | LMNA (0.42) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL11765090 | 0.76 | CA12 (0.42) | LMNATSHR | |
| SCHEMBL13692258 | 0.75 | NFKB1 (0.44) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL31040409 | 0.75 | LMNA (0.48) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL3510313 | 0.75 | ALDH1A1 (0.33) | TSHR | |
| Hydrochloric Acid SCHEMBL17101355 | 0.74 | DNM1 (0.43) | TSHRKMT2AHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746326-A4 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS INC (US) | 2000-06-14 | — | — | EP | disclosed |
| EP-0746326-A1 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995018623-A1 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |