Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147148 | 0.77 | LMNA (0.50) | LMNAMMP12MMP13KEAP1NPY5R | |
| SCHEMBL26574728 | 0.74 | LMNA (0.52) | LMNAMMP12MMP13KEAP1NPY5R | |
| SCHEMBL8009670 | 0.74 | TTR (0.49) | LMNAKEAP1NPSR1MAPTTTR | |
| SCHEMBL8000595 | 0.73 | LMNA (0.48) | LMNAKEAP1NPSR1MAPTTTR | |
| SCHEMBL7622927 | 0.72 | NPSR1 (0.47) | LMNAMMP12MMP13KEAP1NPY5R | |
| SCHEMBL11485002 | 0.71 | MMP12 (0.52) | LMNAMMP12MMP13NPY5RMAPT | |
| SCHEMBL8009574 | 0.70 | LMNA (0.45) | LMNAKEAP1NPSR1TTRKMT2A | |
| SCHEMBL8009573 | 0.70 | LMNA (0.45) | LMNAKEAP1NPSR1TTRKMT2A | |
| SCHEMBL8006393 | 0.69 | BCAT1 (0.50) | LMNANPSR1MAPTTTRKMT2A | |
| SCHEMBL5819845 | 0.68 | LMNA (0.46) | LMNAMMP12MMP13KEAP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | claimed |
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | disclosed |