Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CRHBP | P24387 | 3/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736347 | 0.97 | MAPT (0.44) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL8001928 | 0.93 | MAPT (0.41) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL5734469 | 0.84 | RAB9A (0.43) | MAPTGAASMN1; SMN2FFAR2KMT2A | |
| SCHEMBL5734992 | 0.74 | GAA (0.34) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL7994622 | 0.70 | FFAR2 (0.32) | FFAR2ALDH1A1NTRK1 | |
| SCHEMBL3036063 | 0.67 | ALDH1A1 (0.40) | MAPTGAACRHBPCRHR2FFAR2 | |
| SCHEMBL7998418 | 0.66 | MAPT (0.33) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29167157 | 0.65 | MAPT (0.58) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL23453428 | 0.65 | MAPT (0.57) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL5739656 | 0.63 | MAPT (0.51) | MAPTGAACRHBPCRHR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001055139-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |