Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496919 | 0.92 | SIGMAR1 (0.41) | CSF1RFLT3ABL1SRCFGFR1 | |
| SCHEMBL9915261 | 0.90 | ALK (0.37) | CSF1RFLT3ABL1ALDH1A1 | |
| SCHEMBL8000939 | 0.88 | KCNH2 (0.36) | CSF1RFLT3PTGS2JAK3MAPK14 | |
| SCHEMBL12831883 | 0.88 | RAF1 (0.37) | PTGS2JAK3HDAC1KDM4EALDH1A1 | |
| SCHEMBL1496941 | 0.88 | SIGMAR1 (0.43) | FGFR1SUCNR1SIGMAR1NAMPT | |
| SCHEMBL1496917 | 0.86 | SIGMAR1 (0.40) | ACHEBACE1SUCNR1SIGMAR1HDAC1 | |
| SCHEMBL3224387 | 0.86 | SIGMAR1 (0.42) | CSF1RFLT3ABL1SRCFGFR1 | |
| SCHEMBL1496887 | 0.86 | HDAC1 (0.40) | ACHEBACE1CSF1RFLT3ABL1 | |
| SCHEMBL1496879 | 0.85 | CSF1R (0.36) | CSF1RFLT3ABL1SRCMAPK14 | |
| SCHEMBL8001252 | 0.85 | CSF1R (0.38) | CSF1RFLT3ABL1SRCMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009142321-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | 参天製薬株式会社 (JP) | 2009-11-26 | — | — | WO | disclosed |