Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 2/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 5/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25664269 | 0.79 | GAA (0.37) | GAAMAPTXIAPSMYD3ELANE | |
| SCHEMBL25877347 | 0.78 | GAA (0.40) | GAAMAPT | |
| SCHEMBL3229202 | 0.75 | CHRNB2 (0.47) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL7946404 | 0.74 | REN (0.32) | GAAMAPTELANEREN | |
| SCHEMBL7934107 | 0.72 | CASP1 (0.44) | — | |
| SCHEMBL1931082 | 0.72 | DRD2 (0.41) | GAAXIAPBIRC2 | |
| SCHEMBL1931296 | 0.72 | DRD2 (0.41) | GAAXIAPBIRC2 | |
| SCHEMBL12552719 | 0.72 | DRD2 (0.41) | GAAXIAPBIRC2 | |
| SCHEMBL1550688 | 0.71 | DRD2 (0.47) | GAA | |
| SCHEMBL1366811 | 0.69 | GAA (0.60) | GAAMAPTSMYD3RENMASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |