Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 4/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1550068 | 0.78 | STAT6 (0.39) | — | |
| SCHEMBL3223565 | 0.78 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL6880594 | 0.75 | REN (0.35) | RENDGAT1MAPTGAA | |
| SCHEMBL8002379 | 0.74 | GAA (0.40) | RENELANEMAPTGAA | |
| SCHEMBL7933396 | 0.73 | GRM1 (0.40) | RENMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL1549663 | 0.73 | STAT6 (0.38) | — | |
| SCHEMBL12553013 | 0.71 | CASP1 (0.40) | — | |
| SCHEMBL1549976 | 0.71 | CYP51A1 (0.40) | — | |
| SCHEMBL19856859 | 0.71 | CYP51A1 (0.40) | — | |
| SCHEMBL1550050 | 0.71 | CYP51A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |