Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10039301 | 0.88 | HPGD (0.60) | LMNAHPGDCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL24480430 | 0.86 | HPGD (0.58) | LMNAHPGDCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22179231 | 0.85 | ALDH1A1 (0.50) | LMNAKDM4EHPGDCHRNB2CHRNA3 | |
| SCHEMBL25856197 | 0.83 | LMNA (0.45) | LMNAKDM4EHPGDALDH1A1TSHR | |
| SCHEMBL19203828 | 0.81 | HTT (0.61) | LMNAHPGDCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL8226164 | 0.81 | LMNA (0.49) | LMNAHPGDCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL15450906 | 0.81 | KDM4E (0.51) | LMNAKDM4EPOLBCYP3A4CYP2C19 | |
| SCHEMBL21087637 | 0.81 | HPGD (0.63) | LMNAKDM4EHPGDCHRNB2CHRNA3 | |
| SCHEMBL17546310 | 0.81 | HPGD (0.52) | LMNAKDM4EHPGDCHRNB2CHRNA3 | |
| SCHEMBL18949269 | 0.81 | KDM4E (0.56) | KDM4EPOLBCYP3A4CYP2C19CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108117-A1 | MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177 | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | WO | disclosed |