Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.30 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12356928 | 1.00 | CTSB (0.32) | CTSBPPP3CBABCC1ABCC2ABCG2 | |
| SCHEMBL10247430 | 0.94 | — | — | |
| SCHEMBL313700 | 0.94 | CTSB (0.32) | CTSBPPP3CB | |
| SCHEMBL8004477 | 0.94 | CTSB (0.32) | CTSBPPP3CB | |
| SCHEMBL313402 | 0.91 | CTSS (0.34) | CTSBPPP3CBABCC1ABCC2ABCG2 | |
| SCHEMBL15216085 | 0.89 | UCHL1 (0.36) | CTSBPPP3CBABCC1ABCC2ABCG2 | |
| SCHEMBL8002444 | 0.89 | UCHL1 (0.36) | CTSBPPP3CBABCC1ABCC2ABCG2 | |
| SCHEMBL12369706 | 0.86 | CTSS (0.32) | CTSBPPP3CB | |
| SCHEMBL15216171 | 0.84 | CTSB (0.35) | CTSBPPP3CB | |
| SCHEMBL10247227 | 0.84 | UCHL1 (0.36) | CTSBPPP3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003659-B2 | Macrocyclic serine protease inhibitors | INDENIX PHARMACEUTICALS, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090202480-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090202480-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | SERPINB1, SPINT2, PRSS1 | CTSB 55/4885PPP3CB 297/4885ABCC1 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.