Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PDXK | O00764 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16385303 | 0.80 | HSD17B1 (0.52) | P2RX7BACE1GRIA2S1PR1CNR2 | |
| SCHEMBL8023947 | 0.79 | PTGER4 (0.48) | P2RX7S1PR1 | |
| SCHEMBL14524935 | 0.79 | ALOX5 (0.44) | S1PR1GRIN1GRIN2BNOTUM | |
| SCHEMBL7941960 | 0.78 | P2RX7 (0.46) | P2RX7S1PR1GRIN1GRIN2BHDAC1 | |
| SCHEMBL8028548 | 0.78 | KDM4E (0.47) | P2RX7GRIN1GRIN2BKDM1A | |
| SCHEMBL25480188 | 0.75 | CYP2D6 (0.45) | S1PR1 | |
| SCHEMBL21753409 | 0.75 | CBFB (0.44) | P2RX7S1PR1 | |
| SCHEMBL1096478 | 0.74 | PSEN1 (0.42) | P2RX7HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL16385279 | 0.74 | KDM4E (0.48) | KDM1A | |
| SCHEMBL12970151 | 0.74 | KDM1A (0.53) | CNR2NOTUMKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |