Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyl Phosphonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | GABBR2 | O75899 | 5/20 | 0.50 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Phosphonate SCHEMBL28529800 | 1.00 | — | — | |
| Phosphoric Acid SCHEMBL1831539 | 0.86 | ALDH1A1 (0.61) | TSHRALDH1A1GABBR2GABBR1CYP1A2 | |
| Phosphoric Acid SCHEMBL1832300 | 0.86 | ALDH1A1 (0.61) | TSHRALDH1A1GABBR2GABBR1CYP1A2 | |
| Phosphoric Acid SCHEMBL63996 | 0.86 | — | — | |
| Phosphoric Acid SCHEMBL64139 | 0.86 | ALDH1A1 (0.61) | TSHRALDH1A1GABBR2GABBR1CYP1A2 | |
| Methyl Phosphonate SCHEMBL8005468 | 0.86 | CA2 (0.61) | TSHRALDH1A1CA2GABBR2GABBR1 | |
| Methyl Phosphonate SCHEMBL7997206 | 0.86 | CA2 (0.61) | TSHRALDH1A1CA2GABBR2GABBR1 | |
| Methyl Phosphonate SCHEMBL142377 | 0.86 | CA2 (0.61) | TSHRALDH1A1CA2GABBR2GABBR1 | |
| Methyl Phosphonate SCHEMBL2535355 | 0.86 | — | — | |
| Phosphoric Acid SCHEMBL5652669 | 0.83 | ALDH1A1 (0.57) | TSHRALDH1A1GABBR2GABBR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8821646-B1 | Compositions and methods for cleaning and preventing plugging in micro-irrigation systems | LBC CREDIT AGENCY SERVICES, LLC, AS AGENT | 2014-09-02 | — | — | US | disclosed |
| US-6036740-A | GYPSUM FOR AGRICULTURE FERTILIZATION | DEERPOINT GROUP, LLC | 2000-03-14 | — | — | US | disclosed |
| EP-0244584-B1 | COOLING WATER CORROSION INHIBITION COMPOSITION | NALCO CHEMICAL COMPANY (US) | 1992-07-29 | — | — | EP | disclosed |
| US-4929425-A | ACRYLAMIDE COPOLYMERS, INORGANIC PHOSPHATES, ORGANIC PHOSPHONATES | NALCO CHEMICAL COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| US-4752443-A | INORGANIC PHOSPHATE, SULFONIC ACID-SUBSTITUTED ACRYLAMIDE POLYMER | NALCO CHEMICAL COMPANY (US) | 1988-06-21 | — | — | US | disclosed |
| US-4744949-A | ACRYLIC ACID, METHACRYLIC ACID, TERT-BUTYLACRYLAMIDE POLYMERS | NALCO CHEMICAL COMPANY (US) | 1988-05-17 | — | — | US | disclosed |
| US-4735787-A | TALL COATING | NALCO CHEMICAL COMPANY (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0238728-A1 | Corrosion inhibiting | NALCO CHEMICAL COMPANY (US) | 1987-09-30 | — | — | EP | disclosed |
| US-4680124-A | Polyacrylate scale inhibition | NALCO CHEMICAL COMPANY (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0033417-B1 | METHOD OF AND COMPOSITION FOR INHIBITING CORROSION | BETZ EUROPE, INC. (US) | 1985-06-05 | — | — | EP | disclosed |
| US-4303568-A | ACRYLIC ACID-HYDROXYALKYL ACRYLATE COPOLYMER AND A WATER SOLUBLE PHOSPHATE | BETZ LABORATORIES, INC. (US) | 1981-12-01 | — | — | US | disclosed |
| EP-0033417-A1 | Method of and composition for inhibiting corrosion | BETZ EUROPE, INC. (US) | 1981-08-12 | — | — | EP | disclosed |