Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 4/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010874 | 1.00 | THRA (0.49) | THRATHRBPLA2G2AGAARXRA | |
| SCHEMBL8439090 | 1.00 | THRA (0.49) | THRATHRBPLA2G2AGAARXRA | |
| SCHEMBL8000079 | 0.98 | THRA (0.47) | THRATHRBPLA2G2AGAARXRA | |
| SCHEMBL8000062 | 0.94 | RXRA (0.46) | THRATHRBGAARXRA | |
| SCHEMBL8008640 | 0.89 | RXRA (0.44) | THRATHRBRXRA | |
| SCHEMBL25788096 | 0.88 | PLA2G2A (0.60) | THRATHRBPLA2G2ATP53TSHR | |
| SCHEMBL8159583 | 0.82 | CREBBP (0.42) | THRBGAARXRATSHR | |
| SCHEMBL10497889 | 0.80 | SMPD1 (0.50) | THRATHRBPLA2G2A | |
| SCHEMBL10498877 | 0.80 | SMPD1 (0.50) | THRATHRBPLA2G2A | |
| SCHEMBL10498337 | 0.80 | SMPD1 (0.50) | THRATHRBPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000026172-A1 | TRIENOIC RETINOID COMPOUNDS AS RETINOIC ACID RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-05-11 | — | — | WO | disclosed |
| US-5998654-A | SKIN DISORDERS; ANTICANCER AGENTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-12-07 | — | — | US | disclosed |