Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8615828 | 0.99 | METAP1 (0.40) | METAP1NPC1RAB9AGAAMCHR1 | |
| SCHEMBL8023959 | 0.87 | ALDH1A1 (0.42) | METAP1GAALMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL8615141 | 0.86 | ALDH1A1 (0.41) | METAP1GAALMNAKMT2AMEN1 | |
| SCHEMBL8025758 | 0.74 | METAP1 (0.38) | METAP1 | |
| Hydrochloric Acid SCHEMBL8616461 | 0.73 | METAP1 (0.39) | METAP1 | |
| SCHEMBL8008639 | 0.72 | OPRM1 (0.42) | RAB9ALMNAOPRM1FAAHL3MBTL1 | |
| SCHEMBL8019882 | 0.72 | SIGMAR1 (0.35) | METAP1 | |
| Hydrochloric Acid SCHEMBL8615192 | 0.71 | CCR6 (0.35) | METAP1 | |
| SCHEMBL24969105 | 0.70 | ALDH1A1 (0.47) | METAP1GAAMCHR1SMN1; SMN2KMT2A | |
| SCHEMBL7623394 | 0.69 | NPC1 (0.57) | NPC1RAB9AGAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780369-B1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 2000-01-19 | — | — | EP | disclosed |
| EP-0780369-A1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |