Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098047 | 0.95 | GAA (0.36) | SMN1; SMN2LMNATSHRHTTALDH1A1 | |
| SCHEMBL7848182 | 0.89 | GRM5 (0.37) | ALDH1A1KMT2AMEN1GAARXFP1 | |
| SCHEMBL8100190 | 0.84 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAALDH1A1GABRA1GABRG2 | |
| SCHEMBL8011799 | 0.84 | CYP1A2 (0.32) | SMN1; SMN2LMNAALDH1A1GABRA1GABRG2 | |
| SCHEMBL8013343 | 0.83 | GAA (0.38) | SMN1; SMN2LMNAALDH1A1GABRA1GABRG2 | |
| SCHEMBL8316162 | 0.81 | MAPT (0.41) | SMN1; SMN2LMNAALDH1A1GABRA1GABRG2 | |
| SCHEMBL7835755 | 0.81 | ALDH1A1 (0.36) | SMN1; SMN2LMNAHTTALDH1A1KMT2A | |
| SCHEMBL8099222 | 0.81 | GAA (0.38) | HTTALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL8098249 | 0.81 | CYP1A2 (0.33) | SMN1; SMN2LMNAALDH1A1GABRA1GABRG2 | |
| SCHEMBL8100183 | 0.79 | GAA (0.36) | SMN1; SMN2LMNAGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |