Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.68 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.68 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.68 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.68 |
| ▸ | NNMT | P40261 | 4/20 | 0.70 |
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.69 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.69 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.69 |
| ▸ | NSD2 | O96028 | 3/20 | 0.69 |
| ▸ | SETD7 | Q8WTS6 | 3/20 | 0.69 |
| ▸ | PCMT1 | P22061 | 2/20 | 0.69 |
| ▸ | TRDMT1 | O14717 | 2/20 | 0.69 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.69 |
| ▸ | INMT | O95050 | 2/20 | 0.69 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.69 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.69 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.69 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.69 |
| ▸ | RNMT | O43148 | 2/20 | 0.69 |
| ▸ | TPMT | P51580 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL8013453 | 1.00 | NNMT (0.70) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Adenosine SCHEMBL6408986 | 0.95 | NNMT (0.76) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Adenosine SCHEMBL6408967 | 0.95 | NNMT (0.76) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Adenosine SCHEMBL27579066 | 0.89 | NNMT (0.77) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Inosine SCHEMBL8446030 | 0.88 | NNMT (0.55) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Inosine SCHEMBL8446027 | 0.88 | NNMT (0.55) | NNMTDOT1LCARM1EHMT2NSD2 | |
| S-Adenosylhomocysteine SCHEMBL29130128 | 0.88 | DOT1L (0.87) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Adenosine SCHEMBL28045831 | 0.88 | DOT1L (0.78) | NNMTDOT1LCARM1EHMT2NSD2 | |
| Adenosine SCHEMBL1664893 | 0.88 | ADORA3 (0.89) | DOT1LEHMT1KMT2ADPP4MEN1 | |
| Homocysteine SCHEMBL28487110 | 0.87 | NNMT (0.75) | NNMTDOT1LCARM1EHMT2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6020139-A | S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy | ORIDIGM CORPORATION (US) | 2000-02-01 | — | — | US | disclosed |