Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | HNF4A | P41235 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 4/20 | 0.40 |
| ▸ | RXRB | P28702 | 3/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716696 | 0.88 | RXRA (0.62) | RXRACYP26A1HNF4ARXRGRXRB | |
| SCHEMBL8016720 | 0.85 | CYP3A4 (0.56) | RXRACYP3A4CYP26A1HNF4ARXRG | |
| SCHEMBL6907114 | 0.78 | RXRA (0.76) | RXRACYP3A4CYP26A1RXRGRXRB | |
| SCHEMBL7898993 | 0.76 | CYP3A4 (0.73) | RXRACYP3A4CYP26A1RXRGRXRB | |
| SCHEMBL7721760 | 0.75 | RXRA (0.71) | RXRACYP3A4CYP26A1HNF4ARXRG | |
| SCHEMBL2788640 | 0.74 | CYP3A4 (0.70) | RXRACYP3A4CYP26A1RXRGRXRB | |
| SCHEMBL6903012 | 0.73 | RXRA (0.74) | RXRACYP3A4CYP26A1RXRGRXRB | |
| SCHEMBL6236296 | 0.72 | RXRA (0.55) | RXRACYP3A4CYP26A1HNF4ARXRG | |
| SCHEMBL14966394 | 0.72 | MGLL (0.46) | MGLL | |
| SCHEMBL6238178 | 0.72 | RXRA (0.56) | RXRACYP3A4CYP26A1HNF4ARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162815-A | RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| US-6156788-A | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-6015569-A | PYRIDINE OR PYRROLE DERIVATIVES OF POLYCYCLIC AROMATICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-01-18 | — | — | US | disclosed |
| US-5766610-A | USEFUL FOR TREATMENT OF MAMMALIAN SKIN AND HAIR, RHEUMATISM, RESIPIRATORY SYSTEM DISORDER, CARDIOVASCULAR AND VISION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-16 | — | — | US | disclosed |