SCHEMBL8014451

SCHEMBL8014451

OCC(O)/C=C/C(O)CO

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.53
LMNA P02545 3/20 0.40
ALDH1A1 P00352 1/20 0.40
TDP1 Q9NUW8 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.35
THRB P10828 1/20 0.32
TSHR P16473 1/20 0.31
OR51E2 Q9H255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8014456 1.00 AKR1B1 (0.53) AKR1B1LMNAALDH1A1TDP1L3MBTL1
SCHEMBL12927523 0.84 GAPDH (0.50) AKR1B1LMNAALDH1A1TDP1TSHR
Acetone SCHEMBL9744462 0.84 AKR1B1 (0.48) AKR1B1LMNAALDH1A1TDP1TSHR
SCHEMBL28094225 0.82
SCHEMBL6742544 0.80 AKR1B1 (0.57) AKR1B1
SCHEMBL12122486 0.79
SCHEMBL12124671 0.79
SCHEMBL11060400 0.79
SCHEMBL1848490 0.79
SCHEMBL1848491 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661471-B2 Urethane-crosslinked biodegradable elastomers MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2023-05-30 US disclosed
US-11661471-B2 Urethane-crosslinked biodegradable elastomers MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2023-05-30 US disclosed
US-20220213252-A1 URETHANE-CROSSLINKED BIODEGRADABLE ELASTOMERS BIOCANT-CENTER OF INNOVATION AND BIOTECHNOLOGY (PT) 2022-07-07 US disclosed
US-11254781-B2 Urethane-crosslinked biodegradable elastomers MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-02-22 US disclosed
US-20210230343-A1 URETHANE-CROSSLINKED BIODEGRADABLE ELASTOMERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-07-29 US disclosed
US-10982038-B2 Urethane-crosslinked biodegradable elastomers MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2021-04-20 US disclosed
US-10035871-B2 Urethane-crosslinked biodegradable elastomers MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2018-07-31 US disclosed
US-8912304-B2 Polyol-based polymers MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2014-12-16 US disclosed
US-20110008277-A1 POLYOL-BASED POLYMERS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2011-01-13 US disclosed
WO-2008144514-A2 POLYOL-BASED POLYMERS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2008-11-27 WO disclosed
EP-0982283-A2 Method for the separation of polyfunctional alcohols from water-soluble salts in aqueous systems Degussa-Hüls Aktiengesellschaft (DE) 2000-03-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210230343-A1 URETHANE-CROSSLINKED BIODEGRADABLE ELASTOMERS PUF60, XRCC5, XRCC6 AKR1B1 1280/4885LMNA 1441/4885ALDH1A1 250/4885
US-10982038-B2 Urethane-crosslinked biodegradable elastomers PUF60, XRCC5, MUS81 AKR1B1 1312/4885LMNA 1426/4885ALDH1A1 240/4885
US-20110008277-A1 POLYOL-BASED POLYMERS SORD, SUCLG2, SUCLG1 AKR1B1 258/4885LMNA 2190/4885ALDH1A1 1149/4885
US-11254781-B2 Urethane-crosslinked biodegradable elastomers PUF60, XRCC5, XRCC6 AKR1B1 1280/4885LMNA 1441/4885ALDH1A1 250/4885
US-11661471-B2 Urethane-crosslinked biodegradable elastomers PUF60, XRCC5, XRCC6 AKR1B1 1280/4885LMNA 1441/4885ALDH1A1 250/4885
US-20220213252-A1 URETHANE-CROSSLINKED BIODEGRADABLE ELASTOMERS PUF60, XRCC5, XRCC6 AKR1B1 1280/4885LMNA 1441/4885ALDH1A1 250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.