SCHEMBL8015490

SCHEMBL8015490

CCOC(=O)CNCCCc1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 8/20 0.66
PPID Q08752 1/20 0.55
SIGMAR1 Q99720 3/20 0.53
ALOX5 P09917 1/20 0.52
POLB P06746 1/20 0.49
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49
HDAC5 Q9UQL6 1/20 0.49
NCOR2 Q9Y618 1/20 0.49
ALDH1A1 P00352 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4847545 0.95 LTA4H (0.67) LTA4HPPIDSIGMAR1ALOX5HPGD
SCHEMBL7930242 0.92 LTA4H (0.58) LTA4HPPIDSIGMAR1ALOX5POLB
SCHEMBL7415640 0.91 LTA4H (0.63) LTA4HPPIDSIGMAR1ALOX5HDAC3
Hydrochloric Acid SCHEMBL27717592 0.89 LTA4H (0.61) LTA4HPPIDSIGMAR1ALOX5HDAC3
SCHEMBL6136275 0.87 LTA4H (0.67) LTA4HSIGMAR1ALOX5POLBHDAC3
SCHEMBL9543983 0.86 SIGMAR1 (0.58) LTA4HSIGMAR1POLBHPGDKMT2A
SCHEMBL12559711 0.83 PPID (0.64) LTA4HPPIDALDH1A1MAPTHPGD
SCHEMBL5695106 0.81 SIGMAR1 (0.58) LTA4HSIGMAR1
SCHEMBL16761953 0.81 LTA4H (0.66) LTA4HSIGMAR1ALOX5POLB
SCHEMBL75205 0.81 PPID (0.69) LTA4HPPIDALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121325-A Naphthyl compounds promote release of growth hormone MERCK & CO., INC. (US) 2000-09-19 US disclosed
US-5834460-A FOR TREATMENT OF BRAIN OR PSYCHOLOGICAL DISORDERS, ALZHEIMER*S DISEASE, MENTAL RETARDATION OR AUTISM YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1998-11-10 US disclosed
US-5663171-A FOR USE IN HUMANS OR ANIMALS MERCK & CO., INC. (US) 1997-09-02 US disclosed
EP-0696586-A1 SERINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed