Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879440 | 0.84 | LMNA (0.62) | OPRM1OPRD1OPRK1LOXL2SMN1; SMN2 | |
| SCHEMBL16128019 | 0.83 | TAS2R14 (0.49) | OPRM1OPRD1OPRK1LOXL2SRD5A2 | |
| SCHEMBL510046 | 0.82 | LTA4H (0.58) | OPRM1OPRD1OPRK1LOXL2GRIN2D | |
| SCHEMBL8021128 | 0.82 | LMNA (0.50) | OPRM1OPRD1OPRK1SMN1; SMN2TSHR | |
| SCHEMBL30629781 | 0.81 | LOXL2 (0.60) | OPRM1OPRD1OPRK1LOXL2GRIN2D | |
| SCHEMBL26117041 | 0.81 | LOXL2 (0.60) | OPRM1OPRD1OPRK1LOXL2GRIN2D | |
| SCHEMBL21656511 | 0.81 | MAPT (0.60) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL17870379 | 0.81 | GAA (0.49) | OPRM1OPRD1OPRK1LOXL2KCNH2 | |
| SCHEMBL8024751 | 0.80 | SRD5A2 (0.68) | SRD5A2SMN1; SMN2TSHRRXRARXRB | |
| SCHEMBL23361553 | 0.80 | KDM4E (0.58) | OPRM1OPRD1OPRK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |