Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021443 | 0.84 | PDCD1 (0.38) | ALDH1A1MAPTPDCD1CD274DHODH | |
| SCHEMBL8028294 | 0.83 | PDCD1 (0.58) | KDM4EALDH1A1MAPTHPGDPDCD1 | |
| SCHEMBL8012943 | 0.81 | PDCD1 (0.43) | KDM4EALDH1A1MAPTHPGDPDCD1 | |
| SCHEMBL8021445 | 0.81 | XDH (0.44) | ALDH1A1HPGD | |
| SCHEMBL20851317 | 0.76 | HPGD (0.70) | CYP2C9KDM4EALDH1A1POLBMAPT | |
| SCHEMBL3997146 | 0.74 | PTGDR2 (0.43) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL15778700 | 0.74 | KDM1A (0.48) | ALDH1A1MAPT | |
| SCHEMBL3994452 | 0.73 | RAB9A (0.47) | KDM4EHPGDPDCD1CD274NPC1 | |
| SCHEMBL2293149 | 0.72 | RAB9A (0.46) | KDM4ECYP2C19DHODHNPC1TP53 | |
| SCHEMBL5886030 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MAPTPDCD1CD274DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |