Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 6/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | BLVRB | P30043 | 1/20 | 0.37 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943319 | 0.82 | MMP2 (0.40) | MMP2MMP3ALDH1A1HPGDHRH3 | |
| SCHEMBL8021443 | 0.82 | PDCD1 (0.38) | XDHSLC22A12ALDH1A1 | |
| SCHEMBL8017682 | 0.81 | CYP2C9 (0.46) | ALDH1A1HPGD | |
| SCHEMBL9924742 | 0.76 | MMP2 (0.61) | MMP2MMP3ALDH1A1HPGDHRH3 | |
| SCHEMBL3997043 | 0.73 | MMP3 (0.46) | MMP3ALDH1A1HRH3 | |
| SCHEMBL13127142 | 0.72 | ALDH1A1 (0.45) | XDHSLC22A12ALDH1A1ABCC4ABCB11 | |
| SCHEMBL15778700 | 0.72 | KDM1A (0.48) | ALDH1A1 | |
| SCHEMBL3997146 | 0.72 | PTGDR2 (0.43) | ALDH1A1HPGD | |
| SCHEMBL14468631 | 0.72 | TRPV4 (0.54) | PDE4A | |
| SCHEMBL7944912 | 0.71 | TSHR (0.39) | MMP2MMP3ALDH1A1HPGDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |