Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.57 |
| ▸ | FCER2 | P06734 | 2/20 | 0.57 |
| ▸ | MMP2 | P08253 | 15/20 | 0.57 |
| ▸ | MMP3 | P08254 | 9/20 | 0.57 |
| ▸ | MMP9 | P14780 | 3/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.56 |
| ▸ | MMP7 | P09237 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018430 | 1.00 | MMP1 (0.57) | MMP1FCER2MMP2MMP3MMP9 | |
| SCHEMBL7405637 | 0.90 | MMP1 (0.59) | MMP1FCER2MMP2MMP3MMP9 | |
| SCHEMBL30735528 | 0.89 | MME (0.57) | — | |
| SCHEMBL1864186 | 0.89 | MME (0.60) | — | |
| SCHEMBL233445 | 0.89 | MME (0.60) | — | |
| SCHEMBL233444 | 0.89 | MME (0.60) | — | |
| SCHEMBL31174325 | 0.89 | MME (0.60) | — | |
| SCHEMBL30561493 | 0.86 | LTA4H (0.54) | — | |
| SCHEMBL30056652 | 0.85 | MME (0.60) | MMP9MMP8 | |
| SCHEMBL16455221 | 0.85 | CTSL (0.49) | MMP1FCER2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728144-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | DARWIN DISCOVERY LTD (GB) | 2000-01-19 | — | — | EP | disclosed |
| US-5853623-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases | CHIROSCIENCE LIMITED (GB) | 1998-12-29 | — | — | US | disclosed |
| EP-0728144-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | Chiroscience Limited (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013289-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | CHIROSCIENCE LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |