Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | BMP1 | P13497 | 12/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8390504 | 1.00 | MMP13 (0.56) | MMP13BMP1MMP7ALDH1A1MMP1 | |
| SCHEMBL8023829 | 0.95 | BMP1 (0.59) | MMP13BMP1MMP7ALDH1A1MMP1 | |
| SCHEMBL8016632 | 0.92 | MMP7 (0.61) | MMP13MMP7ALDH1A1MMP1MMP2 | |
| SCHEMBL8016625 | 0.92 | MMP7 (0.61) | MMP13MMP7ALDH1A1MMP1MMP2 | |
| SCHEMBL8016762 | 0.92 | MMP7 (0.61) | MMP13MMP7ALDH1A1MMP1MMP2 | |
| SCHEMBL8391505 | 0.90 | ALDH1A1 (0.57) | BMP1MMP7ALDH1A1MMP1MMP2 | |
| SCHEMBL8020743 | 0.88 | MMP2 (0.54) | MMP13MMP7ALDH1A1MMP1MMP2 | |
| SCHEMBL7419926 | 0.88 | MMP7 (0.60) | MMP13BMP1MMP7ALDH1A1MMP1 | |
| SCHEMBL8392360 | 0.86 | MMP7 (0.58) | MMP13MMP7ALDH1A1MMP1MMP2 | |
| SCHEMBL8023780 | 0.84 | MMP7 (0.72) | MMP13BMP1MMP7ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973733-A1 | BIS-SULFONOMIDES HYDROXAMIC ACIDS AS MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5859061-A | MATRIX METALLOPROTEINASE INHIBITORS; TREATING DISEASES INVOLVING CONNECTIVE TISSUE DEGRADATION | PHARMACIA & UPJOHN COMPANY (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998031664-A1 | BIS-SULFONOMIDES HYDROXAMIC ACIDS AS MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1998-07-23 | — | — | WO | disclosed |