Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28117925 | 0.83 | — | — | |
| Tromethamine SCHEMBL8029093 | 0.81 | MEN1 (0.36) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11543356 | 0.73 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1843995 | 0.70 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL593282 | 0.69 | MEN1 (0.43) | MEN1LMNAKMT2A | |
| SCHEMBL5382316 | 0.69 | — | — | |
| Tromethamine SCHEMBL1926230 | 0.69 | ALDH1A1 (0.43) | LMNA | |
| Tromethamine SCHEMBL11787768 | 0.69 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| SCHEMBL27564918 | 0.66 | CA1 (0.32) | — | |
| Tromethamine SCHEMBL7567125 | 0.66 | LMNA (0.67) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635512-B1 | Cyclic phosphites as polymer stabilizers | GEN ELECTRIC (US) | 2000-03-01 | — | — | EP | disclosed |