SCHEMBL8021475

SCHEMBL8021475

C[Si](C)(C)C1=C[CH]c2ccccc2C1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.37
CYP11B2 P19099 2/20 0.32
CYP11B1 P15538 1/20 0.32
PTGS2 P35354 1/20 0.32
MAOA P21397 2/20 0.31
MAOB P27338 2/20 0.31
PARP1 P09874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2743954 0.79 CYP11B2 (0.41) TRPA1CYP11B2CYP11B1PTGS2MAOA
Hydrochloric Acid SCHEMBL8319505 0.76 CYP11B2 (0.42) TRPA1CYP11B2CYP11B1PTGS2MAOA
Hydrochloric Acid SCHEMBL8319503 0.76 CYP11B2 (0.39) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL1923169 0.74 TRPA1 (0.38) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL1452101 0.71 ACHE (0.41) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL15121440 0.71 CYP11B2 (0.41) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL8854215 0.69 ACHE (0.40) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL4313253 0.68 TRPA1 (0.36) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL3469802 0.68 TRPA1 (0.36) TRPA1CYP11B2CYP11B1PTGS2MAOA
SCHEMBL1681314 0.68 TRPA1 (0.36) TRPA1CYP11B2CYP11B1PTGS2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986567-A1 PURE ENANTIOMER METALLOCENE COMPLEXES AND THE PRODUCTION AND USE OF THE SAME Ringwald, Markus (DE) 2000-03-22 EP disclosed
WO-1998052956-A1 PURE ENANTIOMER METALLOCENE COMPLEXES AND THE PRODUCTION AND USE OF THE SAME RINGWALD MARKUS (DE) 1998-11-26 WO disclosed