Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27512363 | 0.83 | L3MBTL1 (0.44) | GRM2GRM3PARP1CES2CES1 | |
| SCHEMBL8008318 | 0.82 | GRM2 (0.52) | GRM2GRM3PARP1MEN1KCNK3 | |
| SCHEMBL8017815 | 0.82 | PARP1 (0.47) | GRM2GRM3PARP1MEN1KMT2A | |
| SCHEMBL8007797 | 0.76 | CES2 (0.42) | GRM2GRM3PARP1CES2CES1 | |
| SCHEMBL8018593 | 0.75 | KMO (0.51) | MEN1KMT2ANPC1HPGDRAB9A | |
| SCHEMBL8018575 | 0.74 | MAPK1 (0.52) | GRM2GRM3CES2CES1MEN1 | |
| SCHEMBL6794912 | 0.69 | GRM2 (1.00) | GRM2GRM3 | |
| SCHEMBL8008096 | 0.69 | KMO (0.55) | PARP1CES2CES1MEN1KCNK3 | |
| SCHEMBL23579339 | 0.68 | HSD11B1 (0.58) | PARP1CES2CES1MEN1KMT2A | |
| SCHEMBL29973506 | 0.68 | HSD11B1 (0.58) | PARP1CES2CES1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252049-A | 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives | PHARMACEUTICA & UPJOHN S P A (IT) | 2000-05-03 | — | — | CN | disclosed |
| EP-0973720-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040344-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-09-17 | — | — | WO | disclosed |