Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9082983 | 0.98 | ALOX5 (0.54) | HSP90AA1LMNAALOX5KMT2AALDH1A1 | |
| SCHEMBL8402761 | 0.81 | LTA4H (0.56) | HSP90AA1KMT2AALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL7915837 | 0.80 | LTA4H (0.54) | HSP90AA1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13901174 | 0.80 | LMNA (0.73) | HSP90AA1LMNAKMT2AALDH1A1MAPK1 | |
| SCHEMBL13042440 | 0.77 | ALOX5 (0.68) | LMNAALOX5ALDH1A1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL7110808 | 0.74 | HSP90AA1 (0.70) | HSP90AA1LMNAKMT2AALDH1A1BACE1 | |
| Hydrochloric Acid SCHEMBL1193911 | 0.74 | HSP90AA1 (0.70) | HSP90AA1LMNAKMT2AALDH1A1BACE1 | |
| SCHEMBL21055737 | 0.74 | ALOX5 (0.63) | LMNAALOX5ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL6223892 | 0.72 | HSP90AA1 (0.68) | HSP90AA1LMNAKMT2AALDH1A1BACE1 | |
| SCHEMBL22026670 | 0.72 | ALOX5 (0.61) | LMNAALOX5ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801769-B1 | HEAT-DEVELOPABLE, PHOTOTHERMOGRAPHIC ELEMENTS COMPRISING A HYDRAZIDE COMPOUND | IMATION CORP (US) | 2000-01-26 | — | — | EP | disclosed |
| EP-0940714-A2 | Hydrazide compounds useful as co-developers for black-and-white thermographic elements | Imation Corp. (US) | 1999-09-08 | — | — | EP | disclosed |
| US-5496695-A | MEDICAL DIAGNOSTIC AND GRAPHIC ARTS FILMS EXPOSED BY LASERS AND LIGHT EMITTING DIODES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-03-05 | — | — | US | disclosed |