Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD1 | P21728 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD5 | P21918 | 2/20 | 0.49 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025384 | 0.85 | ADRA2A (0.48) | DRD2DRD1DRD4DRD5UCHL1 | |
| SCHEMBL8022093 | 0.84 | DRD2 (0.37) | DRD2DRD1DRD4DRD5GRM5 | |
| SCHEMBL8024959 | 0.81 | DRD1 (0.46) | DRD1GRM5ADRA2AADRA1AGRM1 | |
| SCHEMBL8026766 | 0.78 | HRH4 (0.40) | DRD2DRD1DRD4DRD5GRM5 | |
| SCHEMBL8030192 | 0.78 | SCN9A (0.42) | MAOA | |
| SCHEMBL8026577 | 0.78 | GRM5 (0.41) | DRD2DRD1DRD4DRD5GRM5 | |
| SCHEMBL8028625 | 0.77 | GRM5 (0.38) | DRD2DRD1DRD4DRD5GRM5 | |
| SCHEMBL8024479 | 0.76 | BRD4 (0.43) | DRD2DRD1DRD4DRD5GRM5 | |
| SCHEMBL8022070 | 0.73 | MAOA (0.41) | DRD2DRD1ADRA2AADRA1DADRA1A | |
| SCHEMBL8029047 | 0.73 | HTR1A (0.43) | DRD2GRM5GRM1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |