Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | S100B | P04271 | 2/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8026503 | 0.98 | MAOA (0.53) | MAOAPLAUCTSSALDH1A1MEN1 | |
| SCHEMBL8028909 | 0.85 | OPRD1 (0.53) | MAOAPLAUALDH1A1MEN1MAPT | |
| SCHEMBL8023881 | 0.77 | MAOA (0.57) | MAOAPLAUMEN1KMT2AOPRM1 | |
| SCHEMBL1011562 | 0.76 | MAOA (0.46) | MAOAALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL8029002 | 0.76 | MAOA (0.56) | MAOAPLAUKMT2AASIC3 | |
| SCHEMBL8028684 | 0.76 | MAOA (0.56) | MAOAPLAUOPRK1ASIC3 | |
| SCHEMBL8024193 | 0.76 | MAOA (0.56) | MAOAPLAUOPRD1OPRM1OPRK1 | |
| SCHEMBL8012740 | 0.76 | MAOA (0.56) | MAOAPLAUKMT2AASIC3 | |
| SCHEMBL7655001 | 0.76 | MAOA (0.56) | MAOAPLAUALDH1A1MAPTKMT2A | |
| SCHEMBL29557733 | 0.76 | MAOA (0.56) | MAOAPLAUALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |