Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | LGMN | Q99538 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019057 | 0.88 | OPRM1 (0.50) | OPRD1OPRM1MAOATMEM97SIGMAR1 | |
| SCHEMBL8026503 | 0.86 | MAOA (0.53) | OPRD1OPRM1MAOAALDH1A1MEN1 | |
| SCHEMBL8024961 | 0.85 | MAOA (0.51) | OPRD1OPRM1MAOAALDH1A1MEN1 | |
| SCHEMBL1011361 | 0.77 | OPRM1 (0.48) | OPRD1OPRM1MAOATMEM97SIGMAR1 | |
| SCHEMBL8018986 | 0.76 | HPGD (0.50) | MAOAALDH1A1MAPTKMT2AHTT | |
| SCHEMBL8023881 | 0.74 | MAOA (0.57) | OPRM1MAOAHTR2BMEN1KMT2A | |
| SCHEMBL8028683 | 0.74 | TMEM97 (0.56) | MAOATMEM97SIGMAR1ADRA2AADRA2B | |
| SCHEMBL8024193 | 0.73 | MAOA (0.56) | OPRD1OPRM1MAOAADRA2AADRA2B | |
| SCHEMBL8028684 | 0.73 | MAOA (0.56) | MAOAADRA2AADRA2BHRH1HTR2B | |
| SCHEMBL8012740 | 0.73 | MAOA (0.56) | MAOAKMT2APLAUSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |