SCHEMBL8025255

SCHEMBL8025255

FC(F)(F)c1ccc(-c2ccccc2-c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 6/20 0.65
ALDH1A1 P00352 2/20 0.55
TSHR P16473 1/20 0.55
BACE1 P56817 2/20 0.48
KDM4E B2RXH2 1/20 0.47
CYP1A2 P05177 1/20 0.47
POLB P06746 1/20 0.47
CYP2C19 P33261 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MAOB P27338 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.45
CHUK O15111 1/20 0.45
TXNRD1 Q16881 1/20 0.45
NOX4 Q9NPH5 1/20 0.45
JAK2 O60674 1/20 0.45
PSEN1 P49768 1/20 0.44
PSEN2 P49810 1/20 0.44
APH1B Q8WW43 1/20 0.44
NCSTN Q92542 1/20 0.44
APH1A Q96BI3 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17840160 0.97 KIF11 (0.68) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL11310344 0.93 KIF11 (0.77) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL16844169 0.84 KIF11 (0.58) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL28549073 0.84 KIF11 (0.58) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL30394422 0.84 KIF11 (0.58) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL3619599 0.82 ALDH1A1 (0.63) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL398877 0.82 ALDH1A1 (0.58) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL21042072 0.82 KIF11 (0.56) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL29551464 0.82 ALDH1A1 (0.63) KIF11ALDH1A1TSHRBACE1KDM4E
SCHEMBL2841464 0.82 ALDH1A1 (0.58) KIF11ALDH1A1TSHRBACE1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000045435-A1 POLYIMIDES USED AS MICROELECTRONIC COATINGS THE UNIVERSITY OF AKRON (US) 2000-08-03 WO disclosed