SCHEMBL8025490

SCHEMBL8025490

COC(=O)c1cccc2c1CCN(C)C2C

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 3/20 0.51
DRD4 P21917 2/20 0.51
DRD1 P21728 2/20 0.51
DRD5 P21918 1/20 0.51
DRD3 P35462 1/20 0.50
HTR5A P47898 1/20 0.50
ALDH1A1 P00352 4/20 0.40
LMNA P02545 1/20 0.38
TSHR P16473 1/20 0.38
KDM4E B2RXH2 2/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38
ALOX12 P18054 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAOA P21397 3/20 0.38
CFTR P13569 1/20 0.37
TRPA1 O75762 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8025533 0.84 DRD2 (0.43) DRD2DRD4DRD1DRD5MAOA
SCHEMBL8026944 0.81 MAOA (0.37) DRD2DRD4DRD1DRD5SMN1; SMN2
SCHEMBL19500923 0.80 DRD2 (0.45) DRD2DRD4DRD1DRD5DRD3
SCHEMBL22180463 0.79 DRD2 (0.44) DRD2DRD4DRD1DRD5DRD3
SCHEMBL17674733 0.79 DRD2 (0.44) DRD2DRD4DRD1DRD5DRD3
SCHEMBL8018984 0.76 ALDH1A1 (0.47) ALDH1A1TSHRKDM4EHSD17B10HPGD
SCHEMBL17681713 0.76 DRD1 (0.60) DRD2DRD4DRD1DRD5DRD3
SCHEMBL22180437 0.75 DRD1 (0.65) DRD2DRD4DRD1DRD5DRD3
SCHEMBL17681739 0.75 DRD1 (0.65) DRD2DRD4DRD1DRD5DRD3
SCHEMBL8012751 0.75 ADRA2A (0.46) DRD2DRD1ALDH1A1HPGDMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009095253-A1 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS MERZ PHARMA GMBH & CO. KGAA (DE) 2009-08-06 WO disclosed