Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8026944 | 0.84 | MAOA (0.37) | DRD2NOTUMMAOADRD1DRD4 | |
| SCHEMBL8025490 | 0.84 | DRD2 (0.51) | DRD2MAOADRD1DRD4DRD5 | |
| SCHEMBL8018984 | 0.80 | ALDH1A1 (0.47) | PARP1 | |
| SCHEMBL8012751 | 0.78 | ADRA2A (0.46) | DRD2NOTUMMAOADRD1HTR1A | |
| SCHEMBL8022070 | 0.76 | MAOA (0.41) | DRD2NOTUMMAOADRD1HTR1A | |
| SCHEMBL23849740 | 0.74 | DRD2 (0.42) | DRD2NOTUMDRD4 | |
| SCHEMBL8030417 | 0.74 | MEN1 (0.44) | DRD2NOTUMMAOAHTR1A | |
| SCHEMBL8027387 | 0.74 | GID4 (0.44) | DRD2MAOADRD1DRD4DRD5 | |
| SCHEMBL8028688 | 0.74 | ADRA2A (0.50) | DRD2NOTUMMAOADRD1DRD4 | |
| SCHEMBL7978723 | 0.74 | GID4 (0.44) | DRD2MAOADRD1DRD5HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |