Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL7802264 | 0.88 | GAA (0.47) | ERN1KMT2AMAPTHTTCYP1A2 | |
| SCHEMBL307134 | 0.86 | ERN1 (0.65) | ERN1KMT2AMAPTHSD17B10HTT | |
| Glycine SCHEMBL28865263 | 0.84 | ERN1 (0.74) | ERN1KMT2AMAPTHTTALDH1A1 | |
| Lysine SCHEMBL8025630 | 0.80 | GSR (0.46) | ERN1KMT2AMAPTHSD17B10 | |
| Lysine SCHEMBL8025632 | 0.80 | GSR (0.46) | ERN1KMT2AMAPTHSD17B10 | |
| Dimethylformamide SCHEMBL27570110 | 0.77 | ERN1 (0.54) | ERN1KMT2AMAPTHSD17B10HTT | |
| Glycine SCHEMBL8217250 | 0.76 | LOXL2 (0.47) | KMT2AMAPTALDH1A1MEN1TSHR | |
| Cyclohexylamine SCHEMBL8036033 | 0.76 | GAA (0.43) | ERN1KMT2AMAPTHTTCYP1A2 | |
| Cyclohexylamine SCHEMBL8036036 | 0.76 | GAA (0.43) | ERN1KMT2AMAPTHTTCYP1A2 | |
| Glycine SCHEMBL27456820 | 0.76 | CYP1A2 (0.54) | KMT2AMAPTHTTCYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121054-A | DIVIDING FLUIDS AND PRECIPITATES; POSITIONING MULTICOMPARTMENT VESSELS ON SUPPORTS, SPINNING A CENTRIFUGE, ALLOWING PRECIPITATES TO SEDIMENT INTO VESSELS, EXCESS FLUIDS WILL BE EJECTED FROM THE TOP OF THE VESSEL | TREGA BIOSCIENCES, INC. (US) | 2000-09-19 | — | — | US | disclosed |